DEVELOPMENT OF THE CONCEPT OF CARDIOVASCULAR RISK FACTORS FROM THE PERSPECTIVE OF TRANSLATIONAL MEDICINE

High cardiovascular mortality (CVD) determines the relevance of their effective primary and secondary preventive measures, based on principles a clinical-epideomyological approach isolation risk factors (RFs). Until now, CVD have been leading cause deterioration in demographic indicators population all countries. According to WHO, they account for up 31 % deaths 59 deaths. Adherence healthy lifestyle, reduction main RFs at level can prevent 80 premature At same time, clinical manifestations atherosclerosis arise absence “classic” RFs. To improve prediction results possibility using additional criteria, so-called “new” RFs, is being studied. They include accumulation final products glycation, insulin resistance, obesity hyperhomocysteinemia. Insulin resistance hyperhomocysteinemia are thougth be most value integration atherothrombosis diagnosis assessing individual prognosis.Thus, increases under influence huge number different genetic, anatomical, physiological,biochemical, psychoemotional factors, identification markers development an urgent problem modern health care.